Background: Third-generation cephalosporin is widely used for typhoid treatment. In May 2018, India’s National Centre for Disease Control based Antimicrobial resistance surveillance network notified through Tamil Nadu State Surveillance Unit about clustering of ceftriaxone-resistant Salmonella enterica serotype Typhi cases in Tiruchirappalli city, Central Tamil Nadu. Team led by State public health department investigated to identify risk factors.
Conclusion: The cluster of ceftriaxone-resistant Salmonella Typhi was due to eating chicken gravy at hotel X in central Tamil Nadu. We recommended proper processing of chicken and continuing surveillance for ceftriaxone-resistant.