Tag Archives: infectious disease

Europe – Impact of Anthropogenic Changes to Water on Human Pathogens

HPS

The journal ‘Eurosurveillance’ is inviting authors to submit papers for a special issue on the impact of anthropogenic changes to water on human pathogens and the epidemiology of infectious diseases and relevance for public health.

The submission deadline has been extended to 13 May 2015.

Water can act as a solvent for antimicrobials, antifungals, antivirals, pesticides, and heavy metals. The release of such substances in the water can lead to the development of respective resistance in pathogens or related vectors. The resistance can spread between pathogens (e.g. via plasmid exchange), but resistant pathogens can also be propagated further in the environment via currents, or food webs, allowing humans to be exposed in new ways.

The aim of this special issue is to provide examples relevant for European public health, on how anthropogenic changes to water affect epidemiology of human infectious disease and how these changes cause infections with pathogens exhibiting novel drug resistance and/or virulence patterns.
Topics of interest include, but are not limited to:

  • emerging opportunistic fungal and bacterial infection acquired in the healthcare setting through contact with water and aerosols;
  • infections caused by organisms from ground water, drinking wells and water reservoirs with resistance to antimicrobials due to increasing concentrations of such substances in these artificial water systems;
  • unusual human outbreaks due to ingestion of pathogens present in foods originating from aquatic environments affected by anthropogenic changes, or due to exposure to pathogens from such environments;
  • issues related to the detection and identification of cases and the proof of anthropogenic change to water as a cause.

For guidance on submitting papers or for further information, consult the Eurosurveillance instructions for authors regarding article formats (at http://www.eurosurveillance.org/Public/ForAuthors/ForAuthors.aspx) or contact the editorial team at eurosurveillance@ecdc.europa.eu. [Source: Eurosurveillance, 16 April 2015. http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=21092]

Research Campylobacter Updates

Eurosurveillance

Differentiation between travel-related and domestic cases of infectious disease is important in managing risk. Incubation periods of cases from several outbreaks of campylobacteriosis in Canada, Europe, and the United States with defined exposure time of less than 24 hours were collated to provide information on the incubation period distribution. This distribution was consistent across the varied outbreaks considered, with 84% (702/832) of cases having an incubation period of four days or less and 1% having an incubation period of eight days or more. The incubation period distribution was incorporated into a model for the number of travel-related cases presenting with symptom onset at given dates after return to their country of residence. Using New Zealand notification data between 2006 and 2010 for cases who had undertaken foreign travel within 10 days prior to symptom onset, we found that 29.6% (67/227 cases; 95% confidence interval (CI): 28.3–30.8%) of these cases were likely to have been domestic cases. When cases with symptom onset prior to arrival were included, the probable domestic cases represented 11.8% (67/571; 95% CI: 11.2–12.3%). Consideration of incubation time distributions and consistent collection of travel start/end dates with symptom onset dates would assist attribution of cases to foreign travel.

Clincal Infectious Diseases

Campylobacteriosis in humans, caused by Campylobacter jejuni and C. coli, is the most common recognized bacterial zoonosis in the EU and US. The acute phase is characterized by gastro intestinal  symptoms. The long-term sequelae (Guillain-Barré Syndrome, reactive arthritis and post-infectious irritable bowel syndrome)  contribute considerably to the disease burden. Attribution studies identified poultry as the reservoir responsible for up         to 80% of the human Campylobacter infections. In the EU, an estimated 30% of the human infections is associated with consumption and preparation of poultry  meat. Until now, interventions in the poultry meat production chain have not been effectively introduced except for targeted  interventions in Iceland and New Zealand. Intervention measures (e.g. biosecurity) have limited effect or are hampered by  economic aspects or consumer acceptance. In the future a multi-level approach should be followed, aiming at reducing the level of contamination of consumer products rather than complete absence of Campylobacter.

CDC  – UK Duck Liver Campylobacter Outbreak

Campylobacter­ spp.–related gastroenteritis in diners at a catering college restaurant was associated with consumption of duck liver pâté. Population genetic analysis indicated that isolates from duck samples were typical of isolates from farmed poultry. Campylobacter spp. contamination of duck liver may present a hazard similar to the increasingly recognized contamination of chicken liver.

 

 

Research – Campylobacter Thermal Survival

IngentaConnectCampylobacter

In Europe, Campylobacter is the leading reported cause of bacterial foodborne infectious disease. Quantifying its ability to survive at chilled and ambient temperatures and identifying the factors involved in variation in its survival may contribute to the development of efficient risk management strategies. A data set of 307 inactivation curves collected from the literature and the ComBase database, combined with 388 experimental curves, was analyzed with a log-linear model to obtain 695 D-values (time for 1 log inactivation). An additional 146 D-values collected from the literature or ComBase were added to the data set, for a total of 841 D-values. Because data were collected from different studies, the experimental conditions were somewhat heterogeneous (e.g., type of media or strain used). The full data set was then split into 19 different study types on which a meta-analysis was performed to determine the effect of temperature (range 0 to 42°C), Campylobacter species (C. coli and C. jejuni), and media (liquid media or meat matrix) on the survival ability of Campylobacter. A mixed-effects model, in which the study type and bacterial species were considered as random effects and the media and temperature as fixed effects, was run using a Bayesian approach. Overall, the model gave satisfactory results, with a residual standard deviation of 0.345 (the model response was the log D-value, expressed in days). In addition, the survival of Campylobacter was greater at 0 than at 42°C, with a log-linear pattern; the z-value (temperature to have a 10-fold decrease of D-value) was estimated to be 26.4°C (95 % interval: 23.9 to 29.4°C). Despite a significant media-species interaction term, it was established that both species were more resistant on the meat matrix than in liquid media. These results may be used to understand how Campylobacter can survive along the food chain, particularly in chilled environments, and consequently be transferred to other foodstuffs.