For 2020, 28 EU/EEA countries reported 4 824 confirmed cases of Shiga toxin -producing Escherichia coli (STEC) infection. The overall notification rate was 1.6 cases per 100 000 population. The highest notification rates were reported in Ireland, Malta, Denmark, and Norway. The EU/EEA notification rate decreased notably in 2020 compared with 2016-2019 due to the COVID-19 pandemic. The highest rate of confirmed cases was observed in 0–4-year-old children, with 8.6 cases per 100 000 population for males and 7.5 cases per 100 000 population for females.