Category Archives: Shigella

USDA – $25 Million to E.coli STEC Research

Food Navigator USA

The US Department of Agriculture (USDA) has awarded a $25m research grant to the University of Nebraska-Lincoln (UNL) to tackle Shiga toxin-producing E. coli (STEC) in the beef supply chain.

As reported on this blog last year the US have decided to ban six E.coli serotypes from the food chain and if the proposal goes through testing will need to begin in March 2012, this is still a very controversial proposal in the US. (link)

Human Cells Build Protein Cages to Trap Invading Shigella

Science Daily

In research on the never-ending war between pathogen and host, scientists at the Pasteur Institute in Paris have discovered a novel defensive weapon, a cytoskeletal protein called septin, that humans cells deploy to cage the invading Shigella bacteria that cause potentially fatal human diarrhea, according to a presentation on Dec. 5, at the American Society for Cell Biology Annual Meeting in Denver.

Pascale Cossart, Ph.D., and Serge Mostowy, Ph.D., reported that the septin cages not only targeted the pathogens for degradation by autophagy, the cell’s internal garbage disposal system, but also prevented the Shigella bacteria from spreading to other cells by impeding the pathogens’ access to actin, a different component of the cell skeleton.