CIDRAP
MCR-1 gene detected in Scottish patient infected with Salmonella
Health officials in Scotland have announced the country’s first detection of antibiotic-resistant bacteria harboring the MCR-1 gene.
According to a report from Health Protection Scotland, investigators with the Scottish Salmonella, Shigella and C. difficile Reference Laboratory identified the gene in an isolate from a Salmonella Enteritides patient who had travelled to Southeast Asia. The agency said the patient is currently recovering and did not require any antimicrobial therapy.
The MCR-1 gene, which can confer resistance to the powerful antibiotic colistin, was first identified in Escherichia coli strains in China in November 15, and since then has been detected in more than 30 countries. MCR-1 has alarmed public health officials because colistin is considered an antibiotic of last resort and is mainly used for bacterial infections that won’t respond to other drugs. In addition, the gene can quickly spread colistin resistance to other bacteria because it’s located on mobile pieces of DNA called plasmids.
The concern is that MCR-1 will latch onto multidrug-resistant bacteria and create infections that doctors can’t treat.
Aug 2 Health Protection Scotland news release
USDA: Antimicrobial resistance ranges from 36% to 44% in E coli
A study by the US Department of Agriculture (USDA) has detected moderate levels of antimicrobial resistance (AMR) in illness-producing Escherichia coli strains from food animals and humans.
The strains were from six serogroups of non-O157 Shiga toxin–producing E coli (n-STEC)—O26, O45, O103, O111, O121, and O145. These serogroups have been identified by the Centers for Disease Control and Prevention as those responsible for the greatest numbers of n-STEC illnesses, hospitalizations, and deaths in the United States. Under USDA rules, any raw ground beef found to contain these bacteria is prohibited from sale to consumers.
Researchers found that 40% of the 138 E coli strains showed resistance to 1 of 15 antimicrobial agents, with AMR prevalence being lower in food animals (36%) than in humans (44%). One animal strain (from serogroups O121 and O145) and one human strain (from serogroup O26) showed extensive resistance.
In the same study, the human and animal E coli strains showed similar susceptibility to 24 disinfectants that were evaluated, with all strains being susceptible to triclosan.
August J Food Prot abstract